Symptoms And Treatment Of Anemia - 1551 Words

Megaloblastic anemia due to dihydrofolate reductase (DHFR) deficiency 1. Abstract Studies have shown that folate deficiency megaloblastic anemia is associated with dihydrofolate reductase (DHFR) deficiency due to mutations in the DHFR gene. In order for tetrahydrofolate (THR) to be able to participate in the de novo synthesis of DNA building blocks, it needs to be regenerated from dihydrofolate (DHR). Regeneration of THR requires DHR to be reduced by the enzyme DHFR. Hence, a deficiency in DHFR will cause inability for THR to regenerate, leading to impaired DNA synthesis and reduced cell divisions. This then results in immature red blood cells (RBC) being released from the bone marrow into the peripheral blood stream. Various other diseases have been associated with megaloblastic anemia including increased risk of cardiovascular disease, birth deformities and/or stunted development and neurological symptoms such as psychosis and hallucinations. Although latest diagnostic tests are less invasive, more sensitive and take into consideration genetic factors, there is still potential room for improvement as there have been instances of misdiagnosis. Overlapping symptoms between megaloblastic anemia and other disorders such as schizophrenia, childhood absence epilepsy and other types of anemia proves a real challenge that needs to be overcome. Better treatment options such as gene therapy should also be looked into in order to improve patients’ quality of life. 2. IntroductionShow MoreRelatedRed Blood Cell and E.g. Sickle-cell Anemia Essay1720 Words   |  7 PagesAnemia is not considerate to be a specific disease; it is a manifestation of many abnormal conditions. 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